a-arrestin 1 (ARRDC1) and b-arrestins cooperate to mediate Notch degradation in mammals
نویسندگان
چکیده
Loredana Puca, Patricia Chastagner, Vannary Meas-Yedid, Alain Israël and Christel Brou* Institut Pasteur and CNRS URA 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France University Pierre et Marie Curie, Cellule Pasteur UPMC, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France Institut Pasteur and CNRS URA 2582, Unité d’Analyse d’Images Quantitative, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France
منابع مشابه
Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.
Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at the cell surface. Mammalian non-activated Notch receptor is internalized, ubiquitylated by the Itch E3 ubiquitin ligase and degraded in the lysosomes. Here, we show that β-arr...
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